BDBM50514399 CHEMBL4467518

SMILES CC(C)c1cccnc1-n1c2nc(c(Cl)cc2c(nc1=O)N1CCN(C[C@@H]1C)C(=O)C=C)-c1c(O)cccc1F

InChI Key InChIKey=VBABZAIFYVBJHE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514399   

TargetGTPase KRas(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514399(CHEMBL4467518)
Affinity DataIC50: 83nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514399(CHEMBL4467518)
Affinity DataIC50: 53nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed