BDBM50514157 CHEMBL4552725

SMILES Cc1cc(C)c(cc1C)-c1cc(NC(=O)CSCC(=O)NC23CC4CC(CC(C4)C2)C3)n(n1)-c1ccccc1

InChI Key InChIKey=NJMLZLFEPYDIKZ-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50514157   

TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514157(CHEMBL4552725)
Affinity DataIC50: 109nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514157(CHEMBL4552725)
Affinity DataIC50: 21nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514157(CHEMBL4552725)
Affinity DataIC50: 231nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514157(CHEMBL4552725)
Affinity DataKd:  2.29E+4nMAssay Description:Inhibition of spin-labelled adenine nucleotide interaction with human P-gp expressed in Escherichia coli BL21 (DE3) assessed as apparent dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514157(CHEMBL4552725)
Affinity DataIC50: 13nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed