BDBM50514078 CHEMBL4582882

SMILES Cc1cc2c(cc1-c1ccc(C[C@H](NC(=O)[C@H]3CC[C@H](CN)CC3)C(=O)Nc3cc(Cl)c4[nH]c(=O)[nH]c4c3)cc1)[nH]cc(C(O)=O)c2=O

InChI Key InChIKey=MRERGFSFJIIPPV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514078   

TargetPlasma kallikrein(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514078(CHEMBL4582882)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human plasma kallikrein preincubated for 15 mins followed by H-Pro-Phe-Arg-AMC substrate addition and measured after 30 mins by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514078(CHEMBL4582882)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514078(CHEMBL4582882)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human factor 11a preincubated for 15 mins followed by Boc-Glu (OBzl) -Ala-Arg-AMC and measured after 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed