BDBM50513357 CHEMBL4590283

SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccc(cc2)-c2ccncc2)cn1

InChI Key InChIKey=QOMJHYUHYMCFHT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50513357   

TargetLysine-specific demethylase 5B(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50513357(CHEMBL4590283)
Affinity DataIC50: 41nMAssay Description:Inhibition of KDM5B (unknown origin) assessed as decrease in demethylation of substrate using peptide (H3(1-21)K4-Me3-GGKBiotin) as substrate and 2OG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50513357(CHEMBL4590283)
Affinity DataIC50: 103nMAssay Description:Inhibition of N-terminal His-tagged recombinant human KDM4A (1 to 359 residues) expressed in Escherichia coli assessed as decrease in demethylation o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 5C(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50513357(CHEMBL4590283)
Affinity DataIC50: 108nMAssay Description:Inhibition of KDM5C (unknown origin) assessed as decrease in demethylation of substrate using peptide (H3(1-21)K4-Me3-GGKBiotin) as substrate and 2OG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4B(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50513357(CHEMBL4590283)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KDM4B (1 to 500 residues) expressed in baculovirus infected Sf9 insect cells assessed as decrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed