BDBM50512854 CHEMBL4468747::US11066363, Compound 37

SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cccc(c1)S(F)(=O)=O

InChI Key InChIKey=TWKWEBMGDALHPN-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50512854   

TargetSRSF protein kinase 1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 36nMAssay Description:Inhibition of SRPK1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 11nMAssay Description:Inhibition of ALK (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSRSF protein kinase 1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 35.6nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetSRSF protein kinase 1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 36nMAssay Description:Inhibition of SRPK1 (unknown origin) incubated for 1 hr in presence of ATP by fluorescent plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 98nMAssay Description:Inhibition of SRPK2 (unknown origin) incubated for 1 hr in presence of ATP by fluorescent plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSRSF protein kinase 1(Human)
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human SRPK1 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human SRPK3 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 422nMAssay Description:Inhibition of human CLK1 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 920nMAssay Description:Inhibition of human CLK2 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CLK3 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 159nMAssay Description:Inhibition of human CLK4 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 225nMAssay Description:Inhibition of human DYRK1A using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 293nMAssay Description:Inhibition of human DYRK1B using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of human DYRK2 using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 6.78E+3nMAssay Description:Inhibition of human DYRK3 using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed