BDBM50512432 CHEMBL4589373

SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3nc4ccc(Oc5ccnc(c5)C(=O)NC)cc4s3)cc2C(F)(F)F)CC1

InChI Key InChIKey=SQQPRORGDVPLSI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50512432   

TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50512432(CHEMBL4589373)
Affinity DataIC50: 3.80nMAssay Description:Inhibition TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50512432(CHEMBL4589373)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
"G. D'Annunzio" University of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50512432(CHEMBL4589373)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of Tie2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50512432(CHEMBL4589373)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
"G. D'Annunzio" University of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50512432(CHEMBL4589373)
Affinity DataIC50: 53nMAssay Description:Inhibition of ABL-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed