BDBM50512302 CHEMBL4441262

SMILES CCC(=O)N1CC[C@@H](C1)Nc1ncnc2n(C)c(nc12)-c1cnn(CC)c1C

InChI Key InChIKey=XZTVMQMWAPLTFI-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50512302   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE11 (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE10 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 94nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 24nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/23/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50512302(CHEMBL4441262)Copy SMILESCopy InChI

Affinity DataIC50: 24nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/23/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL