BDBM50512074 CHEMBL4575813

SMILES ONC(=O)CCCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1

InChI Key InChIKey=QZZCBJMHOODNJW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50512074   

TargetTyrosine-protein kinase JAK2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human JAK2 using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 60 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human JAK1 using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 60 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human TYK2 using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 60 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of recombinant human JAK3 using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 60 mins by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed