BDBM50510904 CHEMBL3912318

SMILES CN(c1c(C)nn(C)c1C)S(=O)(=O)c1c(Cl)cc(CCCN2CCNCC2)cc1Cl

InChI Key InChIKey=YMLFRSAHQNBEFS-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50510904   

TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510904(CHEMBL3912318)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Leishmania major NMT H398N mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510904(CHEMBL3912318)
Affinity DataKi:  2.30nMAssay Description:Inhibition of Leishmania major NMT L421Q mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Human)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510904(CHEMBL3912318)
Affinity DataKi:  19nMAssay Description:Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510904(CHEMBL3912318)
Affinity DataKi:  20nMAssay Description:Inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) expressed in Escherichia coli Rosetta-2 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Human)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510904(CHEMBL3912318)
Affinity DataKi:  26nMAssay Description:Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Human)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510904(CHEMBL3912318)
Affinity DataKi:  49nMAssay Description:Inhibition of human NMT1 Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Human)
Johannes Gutenberg-Universit£T Mainz

Curated by ChEMBL
LigandPNGBDBM50510904(CHEMBL3912318)
Affinity DataKi:  96nMAssay Description:Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed