BDBM50510518 CHEMBL4470592

SMILES CN(C)[C@H]1CCN(C1)c1ccc2c(C(=O)NCC3CCC(F)(F)CC3)c(Cl)ccc2n1

InChI Key InChIKey=PUYAVUFSDFVGJW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50510518   

TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510518(CHEMBL4470592)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510518(CHEMBL4470592)
Affinity DataIC50: 75nMAssay Description:Antagonist activity at P2X7R in LPS-stimulated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed