BDBM50510515 CHEMBL4579375

SMILES COCCOc1ccc2c(C(=O)NCC3CCC(F)(F)CC3)c(Cl)ccc2n1

InChI Key InChIKey=VITAFGZXCYTNKU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50510515   

TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510515(CHEMBL4579375)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510515(CHEMBL4579375)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at P2X7R in LPS-stimulated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed