BDBM50509050 CHEMBL4438309
SMILES CCn1nc(C)cc1C(=O)\N=c1/[nH]c2cc(cc(OC)c2n1C\C=C\Cn1c2c(OCCCN3CCOCC3)cc(cc2[nH]\c1=N/C(=O)c1cc(C)nn1CC)C(N)=O)C(N)=O
InChI Key InChIKey=JGLMVXWAHNTPRF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50509050
Affinity DataEC50: 190nMAssay Description:Agonist activity at human STING HAQ mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of mouse cGAS by ATP consumption assayMore data for this Ligand-Target Pair
Affinity DataEC50: <1nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: 54nMAssay Description:Binding affinity to wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...More data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Binding affinity to human STING G230A/R293Q double mutant cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incu...More data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Binding affinity to wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Agonist activity at human wild type haplotype STING in human PBMC cells assessed as increase in IFN-beta secretion incubated for 3 hrs by luminescenc...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+5nMAssay Description:Agonist activity at human wild type STINGMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as ISG activation incubated for 24 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
Affinity DataEC50: <1nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as ISG activation incubated for 24 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: 186nMAssay Description:Agonist activity at mouse STINGMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Inhibition of wild type human STING by SPA assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual KO-STING cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP report...More data for this Ligand-Target Pair
Affinity DataEC50: 55nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene a...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG-KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gen...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene ass...More data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Activation of STING in human peripheral mononuclear bloodMore data for this Ligand-Target Pair
Affinity DataEC50: <0.100nMAssay Description:Binding affinity to 6His-tagged human STING measured after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Activation of mouse STING expressed in RAW-Lucia ISG cells incubated for 24 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: <0.100nMAssay Description:Activation of human STING (139 to 379 residues) expressed in THP1-Blue ISG cells incubated for 24 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Induction of STING in human PBMC assessed as increase in IFNbeta secretionMore data for this Ligand-Target Pair