BDBM50507295 CHEMBL1232432

SMILES COc1cc2nc(NCCCN(C)C)nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC

InChI Key InChIKey=YYFDMPHIONBOKZ-UHFFFAOYSA-N

Data  4 KI  2 IC50  7 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50507295   

TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Binding affinity to LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Binding affinity to LSD1/CoREST (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Binding affinity to LSD1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataIC50: 778nMAssay Description:Inhibition of human G9a expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human LSD1 (unknown orgin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Binding affinity to LSD1 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  2.43E+5nMAssay Description:Inhibition of human LSD1-CoREST expressed in Escherichia coli assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  243nMAssay Description:Inhibition of human LSD1/CoREST expressed in Escherichia coli using histone H3K4me peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKi:  440nMAssay Description:Inhibition of human LSD1/CoREST using histone H3 peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKi:  440nMAssay Description:Binding affinity to LSD1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKi:  440nMAssay Description:Inhibition of human LSD1-CoREST expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKi:  680nMAssay Description:Inhibition of G9a (unknown origin) assessed as reduction in substrate methylation using histone H3 and SAM as substrate measured after 15 to 60 mins ...More data for this Ligand-Target Pair
In DepthDetails
PubMed