BDBM50506932 CHEMBL2006299

SMILES COc1cccc(CNC(=O)c2ccc(cc2)-c2ccncc2)c1

InChI Key InChIKey=JBLPUDJLELBRHC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50506932   

TargetRho-associated protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50: 160nMAssay Description:Inhibition of human GST-tagged catalytic ROCK1 expressed in baculovirus system using STK S2 peptide substrate and and 33P-ATP after 60 mins by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50: 970nMAssay Description:Inhibition of C-terminal 4His-tagged CYP2D6 (unknown origin) expressed in Escherichia coli by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50: 850nMAssay Description:Inhibition of C-terminal 4His-tagged CYP3A4 (unknown origin) expressed in Escherichia coli by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50: 120nMAssay Description:Inhibition of C-terminal 4His-tagged CYP2C9 (unknown origin) expressed in Escherichia coli by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50: 21nMAssay Description:Inhibition of GST-fused human recombinant ROCK2 (11 to 552 residues) expressed in Spodoptera frugiperda insect cells using STK S2 peptide substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50: 75nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed