BDBM50506780 CHEMBL4550522

SMILES ONC(=O)\C=C\c1ccc(NC(=O)Cc2cccc3ccccc23)cn1

InChI Key InChIKey=DTNVLAIWDVXDJR-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50506780   

TargetHistone deacetylase 4(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human HDAC1 using RHK-K(Ac) as substrate by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using RHK-K(Ac) as substrate by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of human recombinant HDAC7 using fluorogenic class IIa (Bos-Lys(trifluoroacetyl)-AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of human recombinant HDAC9 using fluorogenic class IIa (Bos-Lys(trifluoroacetyl)-AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant HDAC10 using fluorogenic p53 (379-382 residues) (RHKK(Ac)AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human recombinant HDAC11 using fluorogenic class IIa (Bos-Lys(trifluoroacetyl)-AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant HDAC1 using fluorogenic p53 (379-382 residues) (RHKK(Ac)AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant HDAC3 using fluorogenic p53 (379-382 residues) (RHKK(Ac)AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of human recombinant HDAC4 using fluorogenic class IIa (Bos-Lys(trifluoroacetyl)-AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 using fluorogenic p53 (379-382 residues) (RHKK(Ac)AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant HDAC8 using fluorogenic diacetylated p53 (379-382 residues) (RHKK(Ac)K(Ac)AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 156nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic p53 (379-382 residues) (RHKK(Ac)AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50506780(CHEMBL4550522)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human recombinant HDAC5 using fluorogenic class IIa (Bos-Lys(trifluoroacetyl)-AMC) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed