BDBM50506504 CHEMBL4460663

SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2cc(F)c(cc2s1)-c1ccc2C(=O)NCc2c1

InChI Key InChIKey=ZRAYFKGWJMRLBX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50506504   

TargetHepatic triacylglycerol lipase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50506504(CHEMBL4460663)
Affinity DataIC50: 20nMAssay Description:Inhibition of human HL expressed in human COS7 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50506504(CHEMBL4460663)
Affinity DataIC50: 60nMAssay Description:Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50506504(CHEMBL4460663)
Affinity DataIC50: 200nMAssay Description:Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50506504(CHEMBL4460663)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed