BDBM50506503 CHEMBL4475891

SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)nc1

InChI Key InChIKey=POXKHBMFDRWBCM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50506503   

TargetEndothelial lipase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50506503(CHEMBL4475891)
Affinity DataIC50: 30nMAssay Description:Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHepatic triacylglycerol lipase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50506503(CHEMBL4475891)
Affinity DataIC50: 20nMAssay Description:Inhibition of human HL expressed in human COS7 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50506503(CHEMBL4475891)
Affinity DataIC50: 40nMAssay Description:Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed