BDBM50505952 CHEMBL4475667::US11034671, Example 48::US11168095, Example 24

SMILES Cn1cc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3

InChI Key InChIKey=OQSJGBSQFMXXBF-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505952   

LigandPNGBDBM50505952(CHEMBL4475667 | US11034671, Example 48 | US1116809...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate pre-incubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50505952(CHEMBL4475667 | US11034671, Example 48 | US1116809...)
Affinity DataIC50: 25nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50505952(CHEMBL4475667 | US11034671, Example 48 | US1116809...)
Affinity DataKd: <100nMAssay Description:The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan is based on a competition binding assay tha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM50505952(CHEMBL4475667 | US11034671, Example 48 | US1116809...)
Affinity DataIC50: 100nMAssay Description:Table 1: Briefly, 20 μL aliquots of a 1.5× stock of ASK1, STK Substrate 3 and Assay Buffer were distributed in the wells of a white 384 well Opt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent