BDBM50505841 CHEMBL4532034::US11174245, # I-018

SMILES COc1ccncc1-c1cc(ccn1)C(=O)\N=c1/[nH]c2ccccc2n1CC(C)(C)O

InChI Key InChIKey=QWYLFZROSUGBFJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50505841   

TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505841(CHEMBL4532034 | US11174245, # I-018)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Mouse)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505841(CHEMBL4532034 | US11174245, # I-018)
Affinity DataIC50: 700nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50505841(CHEMBL4532034 | US11174245, # I-018)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged wild type EGFR expressed in baculovirus expression system assessed as decrease in phosphorylation of ULigh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50505841(CHEMBL4532034 | US11174245, # I-018)
Affinity DataIC50: 11.9nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [695-1022](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50505841(CHEMBL4532034 | US11174245, # I-018)
Affinity DataIC50: 1.00E+4nMAssay Description:5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent