BDBM50505253 CHEMBL4284857

SMILES CCC(C)CNCC(=O)N1CCc2sccc2C1c1cccc(C)n1

InChI Key InChIKey=KYOIGHSNTIJBPW-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505253   

TargetProtein-cysteine N-palmitoyltransferase HHAT(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50505253(CHEMBL4284857)
Affinity DataIC50: 200nMAssay Description:Inhibition of 3C-FLAG/His8-tagged human HHAT expressed in HEK293 cells assessed as reduction in enzyme-mediated sonic hedgehog (1 to 11 residues) pal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-cysteine N-palmitoyltransferase HHAT(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50505253(CHEMBL4284857)
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of human recombinant HHAT using SHH-FAM peptide as substrate for 30 mins by acylation coupled lipophilic induction of polarization (acyl-c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein-cysteine N-palmitoyltransferase HHAT(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50505253(CHEMBL4284857)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of HHAT in human HEK293a SHH+ cells assessed as inhibition SHH-YnPal tagging measured after 7 hrs by cell-based tagging assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein-cysteine N-palmitoyltransferase HHAT(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50505253(CHEMBL4284857)
Affinity DataEC50:  580nMAssay Description:Inhibition of HHAT in human HEK293a SHH+ cells incubated with compound for 24 hrs followed by transferred into SHH-Light2 cells cellular incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed