BDBM50504092 CHEMBL4525587

SMILES COc1nc(OCc2cccc(c2C)-c2cccc(COc3ccc(CNCCNC(C)=O)c(OC)n3)c2C)ccc1CNCCNC(C)=O

InChI Key InChIKey=ZNRITEYTYHQVTF-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50504092   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50504092(CHEMBL4525587)
Affinity DataEC50:  334nMAssay Description:Inhibition of PD1/PDL1 interaction in human Jurkat cells co-cultured with human U2OS cells expressing PDL1 assessed as reduction in SHP1 recruitment ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50504092(CHEMBL4525587)
Affinity DataIC50: 25nMAssay Description:Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 resid...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50504092(CHEMBL4525587)
Affinity DataEC50:  4.21E+3nMAssay Description:Inhibition of human PD1 stably expressed in human Jurkat T cells co-expressing NFAT-induced luciferase/human PDL1 stably expressed in CHOK1 cells co-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50504092(CHEMBL4525587)
Affinity DataIC50: 125nMAssay Description:Inhibition of human PD-1/PD-L1 interaction by HTRF binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed