BDBM50503875 CHEMBL4435800

SMILES CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(cc1F)-c1ccccc1C(O)=O

InChI Key InChIKey=BSJZYWSFNCKCDR-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50503875   

TargetAngiotensin-converting enzyme(Human)
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Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human ACE using Mca-BK2 as substrate preincubated for 10 mins followed by fluorogenic substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
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Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of APP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
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Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human ECE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
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Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
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Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataKi:  1.30nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Theravance Biopharma Us

Curated by ChEMBL
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed