BDBM50503857 CHEMBL4455412

SMILES Cc1c2CCNC(=O)c2ccc1-c1ccc2[nH]ccc2c1

InChI Key InChIKey=CVMCCIUJSPKJJF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503857   

TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50503857(CHEMBL4455412)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50503857(CHEMBL4455412)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50503857(CHEMBL4455412)
Affinity DataIC50: 4.17E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University

Curated by ChEMBL
LigandPNGBDBM50503857(CHEMBL4455412)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed