BDBM50503114 CHEMBL4447306

SMILES C[C@@H]1Cc2c3ccccc3[nH]c2[C@@](N1CC(C)(C)F)(C)c4c(cc(cc4F)/C=C/C(=O)O)F

InChI Key InChIKey=QGICMPFWBJJTDL-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50503114   

TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503114(CHEMBL4447306)
Affinity DataIC50: 0.398nMAssay Description:Displacement of fluorescent labelled fluormone ES2 from human recombinant GST tagged ER alpha LBD ( 282 to 595 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50503114(CHEMBL4447306)
Affinity DataIC50: 1.30nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as downregulation of ER alpha receptor expression measured after 18 to 22 hrs by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed