BDBM50503097 CHEMBL4559531

SMILES CC(C)(C)NC(=O)N1CC(Cn2nc(C(=O)Nc3ccc(c(Cl)c3)-c3ccc(=O)[nH]n3)c3ccccc23)C1

InChI Key InChIKey=VKTHNGMMHIFEOQ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50503097   

TargetTyrosine-protein kinase ZAP-70(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503097(CHEMBL4559531)
Affinity DataEC50:  7.90E+3nMAssay Description:Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503097(CHEMBL4559531)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of His-tagged/GST-tagged CSK (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503097(CHEMBL4559531)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of His-tagged/GST-tagged LCK (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed