BDBM50502495 CHEMBL4445788::US11834430, Compound 40

SMILES C[C@@H](COc1cccc(c1)-c1ccnn1C)Oc1ccc(cc1C)C#N

InChI Key InChIKey=IPMAECGFJWTQDT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502495   

TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50502495(CHEMBL4445788 | US11834430, Compound 40)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50502495(CHEMBL4445788 | US11834430, Compound 40)
Affinity DataIC50: 9.5nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent