BDBM50502494 CHEMBL4446351::US11834430, Compound 9

SMILES Clc1cc(ccc1OCCOc1cccc(c1)-n1ccnc1C1CC1)C#N

InChI Key InChIKey=MNEOWBDGBJBREB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502494   

TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50502494(CHEMBL4446351 | US11834430, Compound 9)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50502494(CHEMBL4446351 | US11834430, Compound 9)
Affinity DataIC50: 0.100nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent