BDBM50500322 CHEMBL3746912

SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12

InChI Key InChIKey=NHAMBLRUUJAFOY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50500322   

TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500322(CHEMBL3746912)
Affinity DataIC50: 6.14E+3nMAssay Description:Inhibition of p97 ATPase in human A549 cells assessed as accumulation of K48 poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500322(CHEMBL3746912)
Affinity DataIC50: 6.61E+3nMAssay Description:Inhibition of p97 ATPase in human A549 cells assessed as accumulation of CHOP poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500322(CHEMBL3746912)
Affinity DataIC50: 815nMAssay Description:Inhibition of human p97 ATPase incubated for 15 mins by ADP Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500322(CHEMBL3746912)
Affinity DataIC50: 110nMAssay Description:Inhibition of p97 (unknown origin) assessed as reduction in ATPase activity by biomol green reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed