BDBM50500198 CHEMBL3745752

SMILES C[C@@](O)(c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1ccccc1Cl)C(F)(F)F

InChI Key InChIKey=MBAGUBQPZLMGBR-UHFFFAOYSA-N

Data  1 IC50  3 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50500198   

TargetGlucokinase regulatory protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50500198(CHEMBL3745752)
Affinity DataKd:  500nMAssay Description:Binding affinity to human GKRP by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetGlucokinase regulatory protein(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50500198(CHEMBL3745752)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to mouse GKRP by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetGlucokinase regulatory protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50500198(CHEMBL3745752)
Affinity DataIC50: 300nMAssay Description:Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetGlucokinase regulatory protein(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50500198(CHEMBL3745752)
Affinity DataEC50: >1.25E+4nMAssay Description:Inhibition of glucokinase-GKRP binding interaction in mouse hepatocytes assessed as induction of glucokinase translocationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetGlucokinase regulatory protein(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50500198(CHEMBL3745752)
Affinity DataKd:  430nMAssay Description:Binding affinity to rat GKRP by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed