BDBM50498655 CHEMBL1895209

SMILES COc1cc2nc(nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC)N1CCN(C)CC1

InChI Key InChIKey=LDFAJFPHFKEJOI-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50498655   

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 101nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human NSD1-SET using histone H3.1 as substrate incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human NSD2-SET using histone H3.1 as substrate incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of human NSD3-SET using histone H3.1 as substrate incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 100nMAssay Description:Inhibition of EHMT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant EHMT2 G9a using SAM as substrate incubated for 1 hr by microplate luminescence based HMT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human NSD1 SET domain assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human NSD2 SET domain assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of human NSD3 SET domain assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 700nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed