BDBM50497974 CHEMBL3319209

SMILES CC(=O)N1CCC(CC1)c1nccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1

InChI Key InChIKey=ZNPDAYJZIRPRFQ-UHFFFAOYSA-N

Data  12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50497974   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Dog)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A/8B(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE11 (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/3/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Amgen

Curated by ChEMBL

LigandBDBM50497974(CHEMBL3319209)Copy SMILESCopy InChI

Affinity DataIC50: 0.180nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
4/19/2024
Entry Details
Copy Entry DOIPubMed
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