BDBM50496943 CHEMBL3236471::US20240174621, Example AR-25

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N

InChI Key InChIKey=QBAKJEJGYGSTPA-UHFFFAOYSA-N

Data  2 IC50  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50496943   

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataIC50: 3nMAssay Description:Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.100nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.200nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.300nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase CSK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd: >4.00E+4nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Lck(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd: >4.00E+4nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.100nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.200nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd:  0.300nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase CSK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd: >4.00E+4nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Lck(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50496943(CHEMBL3236471 | US20240174621, Example AR-25)
Affinity DataKd: >4.00E+4nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In DepthDetails
US Patent