BDBM50492088 CHEMBL2396962

SMILES [H][C@]12Cc3n[nH]cc3[C@]([H])(N1S(=O)(=O)c1cccc(c1)C(F)(F)F)c1cccc(Cl)c21

InChI Key InChIKey=LGEOWGRTHLRQLS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50492088   

TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50492088(CHEMBL2396962)
Affinity DataIC50: 122nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50492088(CHEMBL2396962)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using Notch as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed