BDBM50489449 CHEMBL2322333

SMILES Cc1nn2c(O)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)C1CCOCC1

InChI Key InChIKey=PAIQLYMIBJFUEX-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50489449   

LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataEC50:  1.58E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataIC50: 126nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataEC50: <3.16E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as reduction of AKT phosphorylation at Ser 473More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489449(CHEMBL2322333)
Affinity DataEC50:  2.51E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as cell growth inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed