BDBM50489436 CHEMBL2322350

SMILES Cc1nn2c(cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(N)=O

InChI Key InChIKey=MPKBKADDZUNUKC-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50489436   

LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataIC50: 25nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataEC50: <3.16E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as reduction of AKT phosphorylation at Ser 473More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataEC50: <3.16E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as cell growth inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataIC50: 631nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50489436(CHEMBL2322350)
Affinity DataEC50: <3.16E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed