BDBM50484297 CHEMBL1837042

SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C2CC(CC1c1cn[nH]c1C2)c1ccccc1

InChI Key InChIKey=HOWZRGMUXMOUAI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50484297   

TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484297(CHEMBL1837042)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484297(CHEMBL1837042)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of amyloid precursor protein in human IMR32 cells after 2 hrs using MBPC-125 substrate by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50484297(CHEMBL1837042)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human SNC-204B8 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed