BDBM50477683 CHEMBL250820

SMILES COc1ccc(CN([C@@H]2CCCCNC2=O)S(=O)(=O)c2ccc(Cl)cc2)cc1F

InChI Key InChIKey=HHLUAUWJQNAVGJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50477683   

TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50477683(CHEMBL250820)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 40 levels in H4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50477683(CHEMBL250820)
Affinity DataIC50: 170nMAssay Description:Inhibition of human gamma secretase in HEK293 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed