BDBM50477029 CHEMBL236591

SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)C)C(=O)Nc1ncc(s1)[C@H](C)CCCC(C)(C)OC

InChI Key InChIKey=OOUQMNMVOKCSIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50477029   

TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477029(CHEMBL236591)
Affinity DataIC50: 117nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477029(CHEMBL236591)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed