BDBM50474149 CHEBI:70073::Corynanrheidine

SMILES [H][C@@]12C[C@@H]([C@H](CC)CN1CCc1c2[nH]c2ccccc12)C(=C/OC)\C(=O)OC

InChI Key InChIKey=NMLUOJBSAYAYEM-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50474149   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataIC50: 5.42E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  72nMAssay Description:Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor mu 1 using [3H]- DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  118nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  1.91E+3nMAssay Description:Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in rat RBL cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  1.91E+3nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  2.57E+3nMAssay Description:Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor kappa 1 using [3H]- U-69,593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of dextromethorphan O-demethylation using dextromethorphan as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50474149(CHEBI:70073 | Corynanrheidine)
Affinity DataKi:  2.88E+3nMAssay Description:Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor delta 1 using [3H]DPDPE as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed