BDBM50470564 CHEMBL4287314

SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@@H]1F

InChI Key InChIKey=VPXFTBZVQMXNLH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50470564   

Target5'-nucleotidase(Human)
Claude Bernard University Lyon 1

Curated by ChEMBL
LigandPNGBDBM50470564(CHEMBL4287314)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Claude Bernard University Lyon 1

Curated by ChEMBL
LigandPNGBDBM50470564(CHEMBL4287314)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant CD73 (27 to 549 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells assessed as reduction in conv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Claude Bernard University Lyon 1

Curated by ChEMBL
LigandPNGBDBM50470564(CHEMBL4287314)
Affinity DataIC50: 240nMAssay Description:Inhibition of CD73 in human NCI-H292 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Claude Bernard University Lyon 1

Curated by ChEMBL
LigandPNGBDBM50470564(CHEMBL4287314)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed