BDBM50469504 CHEMBL4293999
SMILES Fc1ccc2c(noc2c1)C1CCN(CCCCC(=O)c2cc3CCN4c3c(CCC4=O)c2)CC1
InChI Key InChIKey=ACOZPXLCYUQMHS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50469504
Target5-hydroxytryptamine receptor 2A(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 257nMAssay Description:Antagonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux ...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 178nMAssay Description:Antagonist activity at serotonin human 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 min...More data for this Ligand-Target Pair
Affinity DataIC50: 366nMAssay Description:Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubate...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 588nMAssay Description:Antagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -50 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Antagonist activity at dopamine D2 receptor long isoform (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calciu...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.720nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.720nMAssay Description:Displacement of [3H]-ketanserine from serotonin 5-HT2A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H] 7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle homogenates after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Binding affinity to D3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Binding affinity to D2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum homogenates after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]-lysergic acid diethylamide from human serotonin 5-HT6 receptor expressed in CHO cell membranes incubated for 30 mins by liquid s...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Binding affinity to 5HT6 receptor (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 8.60nMAssay Description:Binding affinity to 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 8.60nMAssay Description:Displacement of [3H]-8-OH-DPAT from serotonin 5-HT1A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 77nMAssay Description:Displacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 226nMAssay Description:Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 431nMAssay Description:Displacement of [3H]-prazosin from alpha-1 adrenergic receptor in rat cerebral cortex homogenates incubated for 60 mins by liquid scintillation count...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 616nMAssay Description:Displacement of [3H]-mesulergine from serotonin 5-HT2C receptor in rat brain cerebral cortex homogenates incubated for 15 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: 616nMAssay Description:Binding affinity to 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Guinea pig)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 630nMAssay Description:Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Binding affinity to H1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]-QNB from M1 receptor (unknown origin) in cell membrane homogenates after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]-rauwolscine from adrenergic alpha2 receptor in rat cerebral cotex homogenates after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H] WIN35,428 from rat striatum homogenate DAT after 8 hrs mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H] methylhistamine from histamine H3 receptor in rat cerebral cotex homogenates after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Huazhong University of Science and Technology
Curated by ChEMBL
Huazhong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]-paroxetine from SERT in rat cerebral cotex homogenates after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair