BDBM50465712 CHEMBL4284414

SMILES CCOC(=O)c1ccc(CN(Cc2ccc(cc2)-c2cccc(c2)S(C)(=O)=O)S(=O)(=O)c2c(C)cc(C)cc2C)o1

InChI Key InChIKey=HDZWHJYZJWLTAG-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50465712   

TargetOxysterols receptor LXR-alpha(Human)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465712(CHEMBL4284414)
Affinity DataIC50: 214nMAssay Description:Inverse agonist activity at LXRalpha (unknown origin) expressed in HEK293 cells 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465712(CHEMBL4284414)
Affinity DataIC50: 43nMAssay Description:Inverse agonist activity at LXRbeta (unknown origin) expressed in HEK293 cells 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465712(CHEMBL4284414)
Affinity DataIC50: 160nMAssay Description:Inverse agonist activity at human LXRalpha transfected in human HEK293T cells co-transfected with pSG5 and pGL3/(DR-4)-c-fos-FF-luc/pCMV/Renilla-luc ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465712(CHEMBL4284414)
Affinity DataIC50: 100nMAssay Description:Inverse agonist activity at human LXRbeta transfected in human HEK293T cells co-transfected with pSG5 and pGL3/(DR-4)-c-fos-FF-luc/pCMV/Renilla-luc a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465712(CHEMBL4284414)
Affinity DataIC50: 214nMAssay Description:Inverse agonist activity at LXRalpha in human HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465712(CHEMBL4284414)
Affinity DataIC50: 43nMAssay Description:Inverse agonist activity at LXRbeta in human HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Saint Louis University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50465712(CHEMBL4284414)
Affinity DataKi:  352nMAssay Description:Binding affinity to recombinant human LXRbeta-LBD expressed in Escherichia coli BL21 (DE3) assessed as inhibitory constant incubated for 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed