BDBM50465368 CHEMBL4282665

SMILES [H][C@@]12COC[C@@H](C)N1c1nc(nc(c1OC2)C(C)(C)S(C)(=O)=O)N(C)c1ccn[nH]1

InChI Key InChIKey=IRAFDUYEUVGWMA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50465368   

TargetSerine/threonine-protein kinase ATR(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50465368(CHEMBL4282665)
Affinity DataIC50: 10nMAssay Description:Inhibition of ATR in human HT29 cells assessed as reduction in Chk1 phosphorylation at Ser345 residues after 4 hrs by Alexa Fluor 488 staining based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50465368(CHEMBL4282665)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full length ATR/ATRIP expressed in mammalian expression system using c-Myc-tagged p53 as substrate incubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed