BDBM50465059 CHEMBL4283748::US10550080, Example 35

SMILES Cn1cc(-c2cnc(OCC3CC3)c(Cl)c2)c2ccc(cc12)C(=O)NS(=O)(=O)C1CC1

InChI Key InChIKey=KYKNUVNUVQMZFY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50465059   

TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 52nMAssay Description:Displacement of [3H]-labelled radioligand from human Nav1.7 expressed in HEK293 cells measured after 24 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 86nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells at -60 mV holding potential measured after 600 secs by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells at -40 mV holding potential measured after 600 secs by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 86nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 52nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 1.51E+4nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 82nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465059(CHEMBL4283748 | US10550080, Example 35)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed