BDBM50464987 CHEMBL4290518

SMILES CCS(=O)(=O)Nc1ccc(OC)c(c1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C

InChI Key InChIKey=JTYCVFPHELBGDW-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50464987   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50464987(CHEMBL4290518)Copy SMILESCopy InChI

Affinity DataIC50: 0.320nMAssay Description:Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50464987(CHEMBL4290518)Copy SMILESCopy InChI

Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant full length human ASK1 expressed in HEK293/AP1-Luc cells assessed as reduction in p38 phosphorylation after 18 hrs by HTRF ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL