BDBM50464625 CHEMBL4282981::US11091476, Example 5

SMILES CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc4c(N=C(C)C4(C)CC)c(F)c3)nc2)CC1

InChI Key InChIKey=IFXJYXJVOYKBDP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50464625   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464625(CHEMBL4282981 | US11091476, Example 5)
Affinity DataIC50: 33nMAssay Description:Inhibition of CDK4/Cyclin-D1 (unknown origin) using histone-H1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464625(CHEMBL4282981 | US11091476, Example 5)
Affinity DataIC50: 26nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464625(CHEMBL4282981 | US11091476, Example 5)
Affinity DataIC50: 966nMAssay Description:Inhibition of CDK1/Cyclin-A2 (unknown origin) using histone-H1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G1/S-specific cyclin- 2(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464625(CHEMBL4282981 | US11091476, Example 5)
Affinity DataIC50: 438nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464625(CHEMBL4282981 | US11091476, Example 5)
Affinity DataIC50: 7.53nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent