BDBM50464254 CHEMBL4276816

SMILES CC(O)(c1ccc(cc1)S(=O)(=O)C1SC(=NC1C(F)(F)F)N1CCCCC1)C(F)(F)F

InChI Key InChIKey=AADZRZOWFKIFTL-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50464254   

TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50464254(CHEMBL4276816)
Affinity DataEC50:  3.70E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50464254(CHEMBL4276816)
Affinity DataEC50:  3.70E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50464254(CHEMBL4276816)
Affinity DataEC50:  1.24E+4nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50464254(CHEMBL4276816)
Affinity DataEC50: >2.50E+4nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50464254(CHEMBL4276816)
Affinity DataEC50: >2.50E+4nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50464254(CHEMBL4276816)
Affinity DataEC50: >2.50E+4nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed