BDBM50464110 CHEMBL4238909

SMILES OC(=O)C[C@H](CN1CC[C@@H](CCc2ccc3CCCNc3n2)C1)c1cccc(c1)N1CCOCC1

InChI Key InChIKey=NIVBRIPUAQCFIE-UHFFFAOYSA-N

Data  2 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50464110   

TargetIntegrin alpha-V/beta-8(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human integrin alphaVbeta8 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human integrin alphaVbeta6 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-5(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human integrin alphaVbeta5 expressed in human K562 cells assessed as reduction in cell adhesion to vitronectin after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by Q-patch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 251nMAssay Description:Antagonist activity at human integrin alphaVbeta1 expressed in human A549 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 631nMAssay Description:Antagonist activity at human integrin alphaVbeta3 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 251nMAssay Description:Inhibition of integrin alphavbeta1 (unknown origin) expressed in human A549 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-5(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 50nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to human vitronectin incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-8(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 16nMAssay Description:Inhibition of integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 631nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataIC50: 4nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP1 (242 to 252 amin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataKi:  0.0251nMAssay Description:Binding affinity to human integrin alphaVbeta6 assessed as dissociation constant up to 48 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed