BDBM50463792 CHEMBL4245422

SMILES COCCn1cc(cn1)-c1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12

InChI Key InChIKey=NVLPBDLHCCVMFQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50463792   

TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50463792(CHEMBL4245422)
Affinity DataIC50: 509nMAssay Description:Inhibition of recombinant human GST-tagged JAK2 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50463792(CHEMBL4245422)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50463792(CHEMBL4245422)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of recombinant human GST-tagged TYK2 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50463792(CHEMBL4245422)
Affinity DataIC50: 126nMAssay Description:Inhibition of BTK (unknown origin) using TK-substrate-biotin measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50463792(CHEMBL4245422)
Affinity DataIC50: 7.24E+4nMAssay Description:Inhibition of JAK3 in rat splenocytic T cells assessed as reduction in IL-2-induced cell proliferation after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50463792(CHEMBL4245422)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system using TK-substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed