BDBM50462603 CHEMBL4248209::US11542283, Compound V-8A

SMILES COC[C@H](NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(C)C)B1OCCNCCO1

InChI Key InChIKey=SOGYIICGUUSWIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50462603   

TargetProteasome subunit beta type-1(Human)
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50: 13nMAssay Description:Inhibition of caspase-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50: 7.02nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent